Prote-Life

Product information
Cancer is an abnormal growth of cells. The cells have lost normal control mechanisms and thus are able to expand continuously, invade adjacent tissues, migrate to distant parts of the body, and promote the growth of new blood vessels from which the cells derive nutrients. Cancerous (malignant) cells can develop from any tissue within the body. As cancerous cells grow and multiply, they form a mass of cancerous tissue called a
tumor that invades and destroys normal adjacent tissues. The term tumor refers to an abnormal growth or mass. Tumors can be cancerous or noncancerous (1).

Taking different vitamins, minerals, macronutrients, herbs, and extracts as supplements for cancer, are increasingly used in integrative medicine which helps in strengthen the immune system and may ease the side effects during chemotherapy and radiation (2).

Cancer is often associated with a constellation of responses which together lead to cachexia. The term cachexia defined as a complex metabolic syndrome characterized by loss of muscle. Muscle loss is more rapid in cancer patients. The rate of muscle protein synthesis has been reduced in patients (3).

Life On Prote-Life has Protein Isolate, Glutamic Acid, Colostrum, Green Tea Extract, Lycopene, DHA, Vitamin A, Vitamin B1, Vitamin B2, Niacin, Vitamin B6, Vitamin B12, Folic Acid, Vitamin C, Vitamin E, Iron, Zinc, Manganese, Magnesium, Calcium, Iodine, Flax Seed, Selenium, Evening Primrose in its formulation in which protein isolate which helps in maintenance of muscle mass to improving outcome and quality of life in cancer patients. It also stimulates muscle protein synthesis. Cancer patient's normal dietary intake has minimal effects on muscle protein synthesis (3).  

Proteins are essential nutrients for the human body, it is a nutrient that the body needs to grow and maintain itself (10).

They are one of the building blocks of body tissue, and can also serve as a fuel source. As a fuel, proteins contain 4 kcal per gram (11).

Proteins are polymer chains made of Amino Acids linked together by peptide bonds. During human digestion, proteins are broken down in the stomach to smaller polypeptide chains by Hydrochloric Acid and protease actions. This is crucial for the synthesis of the essential Amino Acids that cannot be biosynthesized by the body (12).

Weight loss is common among people with cancer and is often the first noticeable sign of the disease. As many as 40% of people with cancer report unexplained weight loss at the time of diagnosis, and up to 80% of people with advanced cancer experience weight loss (13).

Life On Prote-Life has Glutamic acid in its formulation. Depletion of glutamine occurs in cancer patients as cancer cells consume glutamine at large scale that is why there is lack of glutamine in the skeletal muscle. Glutamine plays very important roles in tumor cell.  It acts as a nitrogen donor in the nucleotide and Amino acid biosynthesis. Glutamine helps in the uptake of essential Amino acid and it maintains the activation of TOR kinase (4).

L-Glutamic acid is converted into L-Glutamine by L-Glutamine Synthetase. L-Glutamine biosynthesize purines and pyrimidines by contributing 3- and 9-nitrogen groups of purine bases, 2-amino group of guanine, 3-nitrogen group and amino group of cytosine which are the bases of DNA and RNA. L-Glutamine cannot be synthesized in neoplastic cells due to the lower reactivity of L-Glutamine synthetase. Thus an antagonist of this enzyme can interfere with the metabolic process of L-Glutamine and act as anticancer agents. Patients suffering from cancer often develop Glutamine depletion in the muscles due to uptake by tumors and chronic protein metabolism (4).

Life On Prote-Life has green tea extract which acts as anticancer agent. Green tea contains substances called polyphenols, which contribute to its anti-cancer activity. Catechin epigallocatechin-3-gallate (EGCG), it interferes with several of the processes involved in cell replication, causing tumor cell death (apoptosis). It also slows the formation of blood vessels around tumors. Epigallocatechin (ECG), another polyphenol, stops leukemic cells from multiplying in laboratory studies. As a proven antioxidant, green tea extract may repair cell damage.

Life On Prote-Life has Lycopene which acts as antioxidant. Lycopene is a natural pigment that is produced by plants and microorganisms. It acts as an antioxidant and affects the way cells grow and communicate with each other. Lycopene may help in slowing and reducing cancer cell growth, preventing DNA damage, and enhancing enzymes that break down cancer-causing cells (6).

Life On Prote-Life has Colostrum which works as an immune booster it is rich in antibodies. It provides passive immunity. Colostrum contains high amount of proteins, immunoglobulin, lactoferrin and growth factors which are essential for specific functions. Colostrum components like antimicrobial factors, immunoglobulin and growth factor not only benefits physically active person but also used in the treatment of autoimmune disorders while antimicrobial factors provide passive immunity and protection against infections. Lactoferrin, has been investigated as novel therapeutic and it also has anticarcinogenic properties against colon and other cancers (7).

DHA was found to inhibit growth of human colon carcinoma cell, DHA was shown to increase the efficacy of chemotherapy in prostate cancer cells. DHA improves memory, can slow the progression of Alzheimer's disease (9).

Life On Prote-Life is packed with essential Vitamins, Minerals, Macro nutrients, and plant extracts which may be benefitting the cancer patients in some way or the other.

Protein, Magnesium & Calcium contributes to a growth in muscle mass (14).

Protein, Zinc, Manganese, Magnesium & Calcium is needed for the maintenance of normal bones(14).

DHA contributes to maintenance of normal brain function and normal function of the heart (14).

DHA contributes to the maintenance of normal blood triglyceride levels and normal blood pressure (14).

DHA, Vitamin A, Riboflavin & Zinc contributes to the maintenance of normal vision (14).

Vitamin A, Riboflavin, Niacin, Zinc & Iodine contributes to the maintenance of normal skin (14).

Vitamin A, Vitamin B6, Vitamin B12, Vitamin C, Iron, Zinc & Selenium contributes to the normal function of the immune system (14).

Magnesium, Iodine and Calcium contributes to normal energy-yielding metabolism (14).

Riboflavin, Vitamin B6, Vitamin B12, Niacin, Vitamin C, Magnesium & Iodine contributes to normal functioning of the nervous system (14).

Riboflavin, Vitamin C, Vitamin E, Zinc, Manganese & Selenium contributes to the protection of cells from oxidative stress(14).

Riboflavin, Vitamin B6, Vitamin B12, Niacin, Vitamin C, Iron & Magnesium contributes to a reduction of tiredness and fatigue(14).

Vitamin B6 contributes to normal cysteine synthesis and Vitamin B6 & B12 contributes to normal homocysteine metabolism (14).

Vitamin B12, Iron, Zinc, Magnesium & Calcium has a role in the process of cell division (14).

Vitamin C contributes to normal collagen formation for the normal function of bones, cartilage, blood vessels, teeth and gums (14).

Zinc contributes to normal acid-base metabolism, normal carbohydrate metabolism, normal macronutrient metabolism, normal metabolism of fatty acids. Zinc also contributes to normal protein synthesis and maintenance of normal hair and nails (14).

Magnesium contributes to electrolyte balance and normal protein synthesis (14).

References
1.http://www.merckmanuals.com/home/cancer/overview-of-cancer/overview-of-cancer
2.https://www.webmd.com/diet/features/cancer-supplements#2
3
.Muscle protein synthesis in cancer patients can be stimulated with a specially formulated medical food, Clin Nutr. Author manuscript; available in PMC 2014 Mar 25. doi:  10.1016/j.clnu.2011.05.008
4.Glutamic acid as anticancer agent: An overview, Saudi Pharm J. 2013 Oct; 21(4): 337–343.
doi:  10.1016/j.jsps.2012.12.007
5.https://www.mskcc.org/cancer-care/integrative-medicine/herbs/green-tea
6.https://www.mskcc.org/cancer-care/integrative-medicine/herbs/lycopene
7.A Review on Anticancer Property of Colostrum. Research and Reviews Journal of Medical and Health Sciences 1 e-ISSN: 2319-9865 p-ISSN: 2322-0104
RRJMHS | Volume 5 | Issue 4 | September, 2016 
8.https://www.cancer.gov/about-cancer/causes prevention/ risk / diet/ antioxidants -fact-sheet
9
.Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model". Neuron 43 (5): 633–45.doi:10.1016 /j.neuron. 2004.08.013. PMID 15339646
10.Protein and the Body, Division of Agricultural Sciences and Natural Resources, Oklahoma State University
11.en.wikipedia.org/wiki/Protein_(nutrient)
12.Energy and macronutrient requirements for physical fitness in exercising subjects, Clin Nutr. 2010 Aug;29(4):413-23.
doi:10.1016/j.clnu.2010.02.002. E pub 2010 Mar 2.
13
.Weight Loss Approved by the Cancer.Net Editorial Board, 11/2014, cancer.net/navigating-cancer-care/side-effects/weight-loss.
14.http://ec.europa.eu/
nuhclaims/