Magne B6-Life

Product information
Energy metabolism is the method of produce energy from nutrients. Metabolism is maintaining chemical transformation inside the cells of living organisms. Metabolism is broadly
categorised into catabolism and anabolism. Catabolism is nothing but breaking if organic matter and harvesting energy into the condition of cellular respiration. Anabolism uses energy to build components of cells such as proteins and nucleic acids (1).

Energy homeostasis is critical for the survival of species. Therefore, multiple and complex mechanisms have evolved to regulate energy intake and expenditure to maintain body weight (2)

The nervous system is the part of a body that coordinates its voluntary and involuntary actions and transmits signals to and from different parts of its body. The function of the nervous system is to send signals from one cell to others, or from one part of the body to others parts. There are multiple ways that a cell can send signals to other cells, one is by releasing chemicals called hormones into the internal circulation, so that they can diffuse to distant sites.  The nervous system provides "point-to-point" signals neurons project their axons to specific target areas and make synaptic connections with specific target cells (3).

Life On Magne B6-Life has Magnesium which is a mineral that is present in relatively large amounts in the body and Vitamin B6. the average person’s body contains about 25 grams of Magnesium, and about half of that is in the bones. Magnesium is important in more than 300 chemical reactions that keep the body working properly. Magnesium is also used as a laxative for constipation and for preparation of the bowel for surgical or diagnostic procedures. It is also used as an antacid for acid indigestion. Magnesium is also used for treating attention deficit-hyperactivity disorder (ADHD), anxiety, chronic fatigue syndrome (CFS), Lyme disease, fibromyalgia, leg cramps during pregnancy, diabetes, kidney stones, migraine headaches, weak bones (osteoporosis), premenstrual syndrome (PMS), altitude sickness, urinary incontinence, restless leg syndrome, asthma, hay fever, multiple sclerosis, and for preventing hearing loss (4).

Vitamin B6, also called Pyridoxine, Vitamin B6 helps the body make several neurotransmitters, chemicals that carry signals from one nerve cell to another. It is needed for normal brain development and function, and helps the body make the hormones serotonin and norepinephrine which influence mood and melatonin, which helps regulate the body clock.  B6 helps control levels of homocysteine in the blood. Homocysteine is an amino acid that may be associated with heart disease (5).

The metabolism of carbohydrates and fats to produce energy requires numerous Magnesium dependent chemical reactions. Magnesium is required by the adenosine triphosphate (ATP)-synthesizing protein in mitochondria. ATP, the molecule that provides energy for almost all metabolic processes, exists primarily as a complex with Magnesium (Mg ATP) (8).

Vitamin B6 in Amino Acid metabolism makes it a rate limiting cofactor in the synthesis of neurotransmitters such as Dopamine, Serotonin, R-Aminobutyric acid (GABA), noradrenaline and the hormone melatonin.

The synthesis of these neurotransmitters is differentially sensitive to Vitamin B6 levels, with even mild deficiency resulting in preferential down-regulation of GABA and serotonin synthesis, leading to the removal of inhibition of neural activity by GABA and disordered sleep, behaviour, and cardiovascular function and a loss of hypothalamus-pituitary control of hormone excretion. Vitamin B6 also has a direct effect on immune function and gene transcription/expression and plays a role in brain glucose regulation (6)

Magnesium contributes to a reduction of tiredness and fatigue, electrolyte balance, normal energy-yielding metabolism, normal functioning of the nervous system, normal muscle function, normal protein synthesis, normal psychological function (7).

Magnesium helps maintenance of normal bones, maintenance of normal teeth, role in the process of cell division (7).

Magnesium helps in treating Constipation. Taking Magnesium by mouth is helpful as a laxative for constipation and to prepare the bowel for medical procedures (4).

Dyspepsia (heartburn or “sour stomach”). Taking Magnesium by mouth as an antacid reduces symptoms of heartburn, various Magnesium compounds can be used (4).

Taking Magnesium is helpful for treating and preventing magnesium deficiency. Magnesium deficiency usually occurs when people have liver disorders, heart failure, vomiting or diarrhea, kidney dysfunction, and other conditions. High blood pressure during pregnancy (pre-eclampsia and eclampsia). Administering Magnesium intravenously (by IV) or as a shot is considered the treatment of choice for reducing high blood pressure during pregnancy (pre-eclampsia) and for treating eclampsia (4).

Magnesium helps in Ion transport across cell membranes, for the active transport of ions like Potassium and Calcium across cell membranes. Through its role in ion transport systems, Magnesium affects the conduction of nerve impulses, muscle contraction, and normal heart rhythm (8).

Vitamin B6 helps your body make serotonin, a chemical that influences mood. Low levels of serotonin are associated with depression, and some antidepressant medications work by raising levels of serotonin (5).

References
1.energy metabolism journal, www.omicsonline.org/nutrition -disorder -and -therapy/ energy-metabolism -journals.php
2.Energy metabolism, fuel selection and body weight regulation, Int J Obes (Lond). 2008 Dec; 32(Suppl 7): S109–S119.doi:  10.1038/ijo.2008.246
3.Nervous system, en.wikipedia.org/wiki/Nervous_system
4.MAGNESIUM, www.webmd.com/vitamins-supplements/ingredientmono-998-magnesium.aspx?activeingredientid=998
5.Vitamin B6 (Pyridoxine),http://umm.edu /health/medical /altmed/supplement/ vitamin-b6-pyridoxin
6.B Vitamins and the Brain: Mechanisms, Dose and Efficacy—A Review Nutrients. 2016 Feb; 8(2): 68. Published online 2016 Jan 28. doi:  10.3390/nu8020068 PMCID: PMC4772032 PMID: 26828517
7.Magnesium, http://ec.europa.eu/nuhclaims/
8.Magnesium,lpi.oregonstate.edu/mic/minerals/ magnesium