Joint-Life Advance

Product Information
Cartilage is the type of tough connective tissue with a flexible matrix made of collagen, protein
and sugars which covers the ends of your bones at a joint. It also gives shape and support to other parts of your body, such as your ears, nose and windpipe. Healthy cartilage helps you move by allowing your bones to glide over each other. It also protects bones by preventing them from rubbing against each other(1).

A disorder which depletes the cartilage and weakens the joint is called as Osteoarthritis (OA). It also is known as degenerative arthritis, degenerative joint disease or osteoarthritis, is a type of joint disease that results from the breakdown of joint cartilage and underlying bone(2).

The most common symptoms are joint pain and stiffness. Other symptoms may include joint swelling, decreased range of motion and when the back is affected weakness or numbness of the arms and legs. The most commonly involved joints are those near the ends of the fingers, at the base of the thumb, neck, lower back, knees and hips(3).

Why Life-On Joint-Life Advanced Formulation supplement?

Life-On Joint Care Advanced Formulation supplement is a perfect fusion of nutrients which has several benefits than any other existing products in market. It is carefully formulated keeping in mind with most essential ingredients like Glucosamine Sulphate and Chondroitin Sulphate, they have been used in various forms for OA for more than a decade and have recently acquired substantial popularity because of their safety and these remedies would have great utility in the treatment of OA.Methyl Sulfonyl Methane (MSM) is an organosulfur compound which treats Mucous-membrane inflammation. Whereas Vitamin D3 helps in the absorption of Calcium in the body and maintain bone mineral density.

Vitamin B12 and Vitamin C, Folic Acid, Zinc and Copper will provide additional benefits for this formulation.Glucosamine Sulphate and Chondroitin Sulphate help in repairing the cartilage extracellular matrix. It Increases Proteoglycan synthesis by formation of Chondrocytes. Chondroitin Sulphate inhibit the activity of degradative enzymes. Implies “Anti-osteoarthritic” helps in reducing Osteoarthritis of knee and hip joints(4).

MSM helps with mitigation of OA symptoms and decreases joint degeneration and Cartilage deterioration(5).

MSM supports in building healthy connective tissues like tendons, Ligaments and muscles. It decreases the pressure inside the cell by removing toxins. Taurine is a Sulfur-containing Amino Acid formed from methionine. Taurine stabilizes cell membranes. Methionine contains sulfur, detoxifies cells and is involved in pain relief(6).

Vitamin B12 contributes in the functioning of nervous system and homocysteine metabolism. It plays role in formation of red blood cells and cell division(7).

Vitamin C contributes in collagen formation of joint tissues and function of blood vessels, nervous system and skin. It protects cells form oxidative stress(7).

Vitamin D contributes in absorption and utilization Calcium and maintains blood Calcium levels helps in functioning of bones and muscle tissues. Vitamin D helps to reduce the loss of bone mineral density in post-menopausal women.  A risk factor for Osteoporotic bone fractures (claim is only used when at least 15 μg of Vitamin D per daily portion)(7).

Zinc helps in DNA synthesis, Carbohydrate metabolism and Fatty Acids metabolism. It maintains Testosterone levels in the body(7).

Folic acid increases maternal folate status. Low maternal Folate status is a risk factor in the development of neural tube defects in the developing foetus (claim used when daily intake at least 400 μg)(7).

Copper helps in maintaining the connective tissues all over the body and protects the cells from oxidative stress(7).

References
1.http://www.art
:cartilage disorders,nlm.nih.gov/medlineplus/cartilagedisorders.html
2.http://www.art
:Atlas of Osteoarthritis, Springer. 2015. p. 21.ISBN 9781910315163."Osteoarthritis”
3.National Institute of Arthritis and Musculoskeletal and Skin Diseases. April 2015. Retrieved 13 May 2015.
4.The Efficacy Of Glucosamine And Chondroitin Sulfate In The Treatment Of Osteoarthritis: Are These Saccharides Drugs Or Nutraceuticals?, Biomedical Papers, 2005 (Vol. 149), Issue 1
5.Glucosamine and Chondroitin Sulfate and Osteoarthritis Food Advisory Committee: Petition Summaries.
6.Methylsulfonylmethane Sulfur (MSM) holistic health journal article MSM.
7.European Union Register on Nutritional and Health Claims.