Prosta-Life

Product information 
The prostate is a muscular, walnut-sized gland that surrounds part of the urethra, the tube that transports urine and sperm out of the body. A part of the male reproductive system, the prostate secretes seminal fluid, a milky substance that combines with sperm produced in the testicles to form semen(1).

The prostate is prone to two main conditions:
Prostatitis: Infection or inflammation of the prostate. Prostatitis can cause burning or painful urination, the urgent need to urinate, trouble urinating, difficult or painful ejaculation, and pain in the area between the scrotum and rectum (known as the perineum) or in the lower back(2).

Benign Prostatic Hyperplasia: Aging-related enlargement of the prostate gland. Benign Prostatic Hyperplasia (BPH) can make the prostate compress the urethra and slow or even stop the flow of urine. BPH affects about three-quarters of men over age 60(2).

Causes that may affect prostate health in men Age – the risk rises as you get older, and most cases are diagnosed in men over 50 years of age(4)

Family history – having a brother or father who developed prostate abnormality or prostate cancer before age 60 seems to increase your risk of developing it(4)

Obesity – recent research suggests that obesity and prostate cancer are related. a person having a balanced diet and regular exercise may lower your risk of developing prostate cancer(4).

Hormonal imbalance - Changes in the balance of hormones in your body as you get older may cause cells in the prostate gland to grow(3).

Saw palmetto mechanism of action on prostrate health liposterolic extract of saw palmetto berries helps in reducing tissue uptake of both testosterone and dihydrotestosterone (DHT) by more than 40%, suggesting antiandrogenic activity(5).

The extract inhibits the binding of DHT to its receptor and blocked conversion of testosterone to DHT by inhibiting 5-alpha-reductase activity. The berries also inhibit cyclooxygenase and 5-lipoxygenase pathways, thereby preventing the biosynthesis of inflammation producing prostaglandins and leukotrienes(5).

Other mechanisms attributed to benefits in benign prostatic hypertrophy are. it includes the blocking of estrogen receptor activity in the prostate as well as bladder muscle antispasmodic and anti-inflammatory activities(5).

Nettle leaf extract mechanism of action on prostrate health Nettle extract inhibits several inflammatory actions that are responsible for the symptoms of seasonal allergies. They include the antagonist and negative agonist activity against the histamine-1 (H1) receptor and inhibition of prostaglandin formation via inhibition of cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2), hematopoietic prostaglandin D2 synthase (HPGDS) and key enzymes in pro-inflammatory pathways(6).

Life On Prosta-Life has saw palmetto extract and nettle leaf extract.Saw Palmetto helps countering effects of male sex hormones such as testosterone and DHT. It appears to reduce levels of these hormones in body tissues like the prostate(5).

Saw Palmetto reduces the conversion of testosterone to DHT, its more potent form. Saw palmetto berry extracts also reduce inflammation and  swelling(5)

Saw Palmetto extract was found to slow the growth of normal prostate cells and increase their sensitivity to radiation, while not affecting prostate cancer cells(5).

Saw Palmetto helps in treating benign prostatic hypertrophy (BPH). Several clinical trials and meta-analyses have shown that saw palmetto improves urinary tract symptoms associated with BPH(5).

Helps in promoting urination, study suggests an increase in urine flow, with an herbal combination formula including saw palmetto(5)

Nettle Leaf extract may help in treating benign prostatic hypertrophy (BPH). When combined with other herbs(6).

Nettle Leaf Extract helps in promoting urination, Nettle is a known diuretic.it also helps in treating urinary tract disorders and relieve difficult or painful urination. Nettle was shown to have beneficial effects(6)

Nettle Leaf Extract helps in reducing inflammation; Nettle have anti-inflammatory activities(6).

References
1.  http://www.healthcommunities.com/prostate/ prostate-gland.shtml
2. https://www.health.harvard.edu/topics/prostate-health -and-disease#
3.  http://www.devon.gov.uk/wellbeing-enlarged prostate.pdf
4.  https://www.nhs.uk/conditions/prostate-cancer/causes/
5. https://www.mskcc.org/cancer-care/integrative-medicine/herbs /saw-palmetto
6. https://www.mskcc.org/cancer-care/integrative-medicine/ herbs/nettle